Velusetrag hydrochloride

Research use only, not for human use.

Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors.

Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors; displays >25-fold selectivity over other biogenic amine receptors, and no effect on hERG channels; increases the contractility of the canine antrum, duodenum and jejunum with higher potency than tegaserod, demonstrates robust in vivo activity in the guinea pig, rat and dog gastrointestinal tracts.Other Indication Phase 2 Clinical

TD-5108

Endocrinology/Hormones

5-HT Receptor

5-HT Receptor

Other Indications

Other Disease

866933-51-9

541.10

C25H37ClN4O5S

>98% (HPLC)

——

Cl.CC(C)N1C(=O)C(=Cc2ccccc12)C(=O)NC3C[C@@H]4CC[C@H](C3)N4C[C@@H](O)CN(C)S(=O)(=O)C

N-((1R,3R,5S)-8-((R)-2-hydroxy-3-(N-methylmethylsulfonamido)propyl)-8-azabicyclo[3.2.1]octan-3-yl)-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxamide hydrochloride

(-20℃)

With Ice Pack

≥ 2 years